Who can receive a second dose of the mpox vaccine?
Given the current epidemiology in Ontario, Imvamune® is being offered as a two-dose primary series, with at least 28 days between first and second doses for individuals currently eligible for pre-exposure and post-exposure vaccination.
Individuals who are household and/or sexual contacts of someone who meets pre-exposure vaccination eligibility AND are moderately to severely immunocompromised are also eligible to receive 2 doses of Imvamune® at least 28 days apart. For details of the definition of moderately to severely immunocompromised, please see Appendix A in the Mpox Vaccine (Imvamune®) Guidance for Health Care Providers.
Please note, individuals who are eligible for pre-exposure vaccination and post-exposure vaccination who previously received an older generation replicating smallpox vaccine can be re-vaccinated. For individuals with a history of receiving 1 dose of a smallpox vaccine, only a single dose of Imvamune® is recommended.
Moderately to severely immunocompromised household and/or sexual contacts must present with one of the following during their vaccine appointment:
- A completed referral form (PDF) from their health care provider; or
- A current medication bottle or prescription receipt for a medication listed in Mpox Vaccine (Imvamune®) Guidance for Health Care Providers, Table 2 List of Significantly Immunosuppressive Medications.
- The prescription or medication bottle must include the:
- client’s first and last name (must match a piece of identification); and
- address and telephone number of the pharmacy that filled the prescription.
- The prescription must have been prescribed or refilled within the past 6 months.
- Active treatment with B-cell depleting therapies (monoclonal antibodies targeting CD19, CD20 and CD22) must have been completed within the last 12 months.
Eligible individuals can call 311 to book a first or second dose appointment for pre-exposure vaccination; no OHIP card or ID is required.
For post-exposure vaccination, speak with your health care provider regarding a second dose of the vaccine if the risk of exposure is expected to continue beyond 28 days following the first dose.